Professor Brian Dean
Position: NHMRC Senior Research Fellow and Head of Rebecca Cooper Laboratory
Campus: 30 Royal Parade, Parkville VIC 3052 and
Brian Dean is most interested in understanding the molecular pathology of schizophrenia. Dean's major focus of research is on the role of muscarinic receptors in the pathology and treatment of schizophrenia and in using high-throughput screening techniques to identify proteins and transcripts that are altered in the CNS of subjects with schizophrenia. The eventual aim of these studies is to identify new drug targets that will give the potential to improve the treatment of subjects with schizophrenia.
Brian Dean uses postmortem human CNS to identify proteins and transcripts that are altered in the CNS of subjects with schizophrenia. Altered proteins are identified using 1 or 2D electrophoresis, Western blotting, ELISA assays, in situ radioligand binding with autoradiography, membrane binding assays and both high and low pressure chromatography. Changes in levels of transcripts are identified using in situ hybridisation, Northern blot analyses and quantitative PCR.